Thyroid Bodily hormones, Sedative Hypnotics, Non-Steroidal Anti-Inflammatory Agents, Benzodiazepines, as well as Decongestants: Although additional certain communication research studies were not executed, Singulair was made use of concomitantly with a vast array of frequently recommended medications in scientific studies without evidence of professional damaging interactions. These medications included thyroid bodily hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, and decongestants.
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Cytochrome P450 (CYP) Enzyme Inducers: Phenobarbital, which induces hepatic metabolic process, lowered the location under the plasma concentration curve (AUC) of montelukast about 40 % following a solitary 10-mg dose of montelukast. No dose change for Singulair is advised. It is practical to utilize ideal clinical surveillance when powerful CYP enzyme inducers, such as phenobarbital or rifampin, are co-administered with Singulair.
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Effect of Montelukast on Cytochrome P450 (CYP) Enzymes: Montelukast is a potent prevention of CYP2C8 in vitro. Information from a scientific drug-drug communication research study involving montelukast and also rosiglitazone (a probe substrate agent of medicines mostly metabolized by CYP2C8) in 12 healthy individuals demonstrated that the pharmacokinetics of rosiglitazone are not changed when the drugs are coadministered, showing that montelukast does not prevent CYP2C8 in vivo. Montelukast is not anticipated to modify the metabolic process of medicines metabolized by this enzyme (e. g. rosiglitazone, repaglinide, and also paclitaxel). Based upon more artificial insemination leads to human liver microsomes, restorative plasma attentions of montelukast do not prevent CYP 3A4, 2C9, 1A2, 2A6, 2C19, or 2D6.
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